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Test Code PR3 Proteinase 3 Antibodies, IgG, Serum


Additional Testing Requirements


To distinguish between granulomatosis with polyangiitis and other forms of anti-neutrophil cytoplasmic antibody-associated vasculitis, also order MPO / Myeloperoxidase Antibodies, IgG, Serum and ANCA / Cytoplasmic Neutrophil Antibodies, Serum; alternatively, VASC / Antineutrophil Cytoplasmic Antibodies Vasculitis Panel, Serum may be ordered instead, which initially tests for MPO and proteinase 3 antibodies, with reflex to ANCA when appropriate.



Specimen Required


Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Children's Mercy Hospital Note:

CMH COLLECTION: 1 mL blood in a vacutainer   Preferred: Red gel   Acceptable: Red

Specimen Minimum Volume

0.35 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Useful For

Evaluating patients with clinical features of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, specifically granulomatosis with polyangiitis (GPA), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis

 

Distinguishing between GPA and other forms of ANCA-associated vasculitis, in conjunction with myeloperoxidase antibody and cytoplasmic neutrophil antibody testing

 

Following treatment response or monitoring disease activity in patients with proteinase 3 antibodies

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus OK

Day(s) Performed

Monday through Saturday

Report Available

2 to 3 days

Reporting Name

Proteinase 3 Ab (PR3), S

Reference Values

<0.4 U (negative)

0.4-0.9 U (equivocal)

≥1.0 U (positive)

Reference values apply to all ages.

Method Name

Multiplex Flow Immunoassay

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

83516