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HelpTest Code PQNU Porphyrins, Quantitative, 24 Hour, Urine
Ordering Guidance
This 24-hour urine test should be ordered when the specimen will not reach Mayo Clinic Laboratories (MCL) within 72 hours. If the specimen will reach MCL within 72 hours, order PQNRU / Porphyrins, Quantitative, Random, Urine.
Shipping Instructions
Ship specimen in amber container to protect from light.
Necessary Information
1. 24-Hour volume (in milliliters) is required.
2. Patient's sex is required.
3. Collection date and time should be documented upon completion of the 24-hour collection.
4. Include a list of medications the patient is currently taking.
Specimen Required
Patient Preparation: Patient should not consume any alcohol for the 24 hours before, as well as during, specimen collection.
Supplies:
-Urine Container - Amber, 60-mL (T596)
-Sodium Carbonate, 5 gram (T272)
Container/Tube: Amber, 60-mL urine container
Specimen Volume: 20 to 50 mL
Collection Instructions:
1. Add 5 g of sodium carbonate as preservative at start of collection. This preservative is intended to achieve a pH above 7. Do not substitute sodium bicarbonate for sodium carbonate.
2. Collect a 24-hour urine specimen.
3. The container should be refrigerated and protected from light as much as possible during collection.
4. Record volume and duration. An aliquot should be frozen when collection is complete.
Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.
CMH COLLECTION: urine in urine jug. Keep refrigerated and protect from light during collection.
Specimen Minimum Volume
15 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Frozen | 7 days | LIGHT PROTECTED |
Testing Algorithm
The following algorithms are available:
Useful For
Preferred screening test for congenital erythropoietic porphyria and porphyria cutanea tarda and during symptomatic periods for acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria when specimen transport will be longer than 72 hours
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Day(s) Performed
Monday through Friday
Report Available
2 to 4 daysReporting Name
Porphyrins, QN, UReference Values
Uroporphyrins (Octacarboxyl):
≤30 nmol/24 h
Heptacarboxylporphyrins:
≤9 nmol/24 h
Hexacarboxylporphyrins:
≤8 nmol/24 h
Pentacarboxyporphyrins:
≤10 nmol/24 h
Copropprphyrins (Tetracboxyl)
Males: ≤230 nmol/24 h
Females: ≤168 nmol/24 h
Porphobilinogen:
≤2.2 mcmol/24 h
Method Name
High-Performance Liquid Chromatography (HPLC) with Fluorometric Detection/Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
84110-Porphobilinogen, quantitative
84120-Porphyrins, quantitation and fractionation