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Fluorescence In Situ Hybridization (FISH) Analysis

Collection Requirements

FISH may be performed using fresh tissue from any tissue type that can be used to perform routine cytogenetic testing; tissue touch preparations can also be used

Special Instructions

  • Call Genetics for further information or specific instructions
  • Indicate FISH probes or chromosomal region requested
  • Indicate the reason for referral on requisition

Turn Around Time

1-10 days

Availability

Routine

Lab Processing Instructions

Room temperature

Performing Laboratory

Genetics

Adele Hall Lab Section

Cytogenetics

Instrumentation/Methodology

Fluorescent labeled DNA probes hybridized to chromosomal DNA in interphase or metaphase cell preparations and detected by fluorescence microscopy

Additional Information

Detects diagnostic and prognostic copy number and chromosomal rearrangement events. Monitors response to therapy and opposite sex transplantation status. Testing approach may utilize locus-specific probes and/or repeat -sequence probes for genes or chromosomes of interest. Multi-probe panels may be used for diagnoses that have multiple known aberrations, for example: ALL, AML, MDS/MPN, CLL, PCN

Reference Ranges

See interpretive report