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HelpB Cell Rearrangement
Collection Requirements
Source: blood or bone marrow
Container: EDTA lavender
Volume:
- Preferred: 3 mL in vacutainer
- Minimum: 1 mL in vacutainer
Source: tumor, fresh frozen
Container: sterile cup
Volume: 20 mg
Source: tissue, formalin fixed paraffin embedded
- Slides: 2 unstained sections (4 micron thick sections, sequential cut)
- Scrolls: 5 scrolls (10 microns think in 1.5 mL tube)
Special Instructions
Specify newly diagnosed disease or minimum residual disease; provide tumor % for FFPE and fresh frozen solid tissue
Turn Around Time
7 days
Availability
Routine
Lab Processing Instructions
Specimen: whole blood or bone marrow
Room temperature or refrigerate
Specimen: tumor, fresh frozen
Freeze
Specimen: Formalin fixed parafin embbeded
Room temperature
Performing Laboratory
Adele Hall
Adele Hall Lab Section
Molecular Genetics
Instrumentation/Methodology
PCR/ fragment analysis
Additional Information
IGH (B-cell) gene rearrangement is used as a tool for detecting lymphoproliferative disorders. Detection of a monoclonal IGH rearrangement is suggestive (but, not solely diagnostic) of a neoplastic process whereas polyclonality usually indicates a reactive proliferation.
Reference Ranges
See interpretative report
CPT
81261