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Collection Requirements
Source: blood or bone marrow
Container: EDTA lavender
Volume:
- Preferred: 3 mL in vacutainer
- Minimum: 1 mL in vacutainer
Special Instructions
Specify newly diagnosed disease or minimal residual disease
Turn Around Time
5-8 days
Availability
Routine
Lab Processing Instructions
Specimen: whole blood or bone marrow
Room temperature or refrigerate
Performing Laboratory
Adele Hall
Adele Hall Lab Section
Molecular Genetics
Instrumentation/Methodology
PCR assay with fluorescent fragment analysis
Additional Information
The nucleophosmin (NPM1) mutation (a four base pair insertion in exon 12) is found in half of AML cases that have a normal karyotype; its presence is associated with a good prognosis when FLT3 ITD is absent, and an intermediate prognosis if FLT3 ITD is present.
Reference Ranges
See interpretive report
CPT
81310