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Collection Requirements
Source: blood or bone marrow
Container: EDTA lavender
Volume:
- Preferred: 3 mL in vacutainer
- Minimum: 1 mL in vacutainer
Special Instructions
Specify newly diagnosed disease or minimal residual disease
Availability
Routine
Turn Around Time
5-8 days
Lab Processing Instructions
Specimen: whole blood or bone marrow
Room temperature or refrigerate
Performing Laboratory
Adele Hall
Adele Hall Lab Section
Molecular Genetics
Additional Information
The nucleophosmin (NPM1) mutation (a four base pair insertion in exon 12) is found in half of AML cases that have a normal karyotype; its presence is associated with a good prognosis when FLT3 ITD is absent, and an intermediate prognosis if FLT3 ITD is present.
Instrumentation/Methodology
PCR assay with fluorescent fragment analysis
Reference Ranges
See interpretive report
CPT
81310