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HelpFLT3-ITD
Collection Requirements
Source: blood or bone marrow
Container: EDTA lavender
Volume:
- Preferred: 3 mL in vacutainer
- Minimum: 1 mL in vacutainer
Special Instructions
Specify newly diagnosed disease or minimal residual disease
Turn Around Time
5-8 days
Availability
Routine
Lab Processing Instructions
Specimen: whole blood or bone marrow
Room temperature or refrigerate
Performing Laboratory
Adele Hall
Adele Hall Lab Section
Molecular Genetics
Instrumentation/Methodology
Multiplex PCR assay with fluorescent fragment analysis
Additional Information
Internal tandem duplication (ITD) mutations arise from duplications of the juxtamembrane portion of the FLT3 gene and result in constitutive activation of the protein. This alteration has been identified in approximately 20% to 30% of patients with acute myeloid leukemia and is associated with a worse prognosis.
Reference Ranges
See interpretive report
CPT
81245