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HelpTest Code IDUAW Alpha-L-Iduronidase, Leukocytes
Ordering Guidance
This test is preferred for diagnostic testing. For carrier detection, order IDUA / Mucopolysaccharidosis Type I, IDUA Gene Sequencing with Deletion/Duplication, Varies.
Shipping Instructions
For optimal isolation of leukocytes, it is recommended the specimen arrives refrigerated within 6 days of collection to be stabilized. Collect specimen Monday through Thursday only and not the day before a holiday. Specimen should be collected and packaged as close to shipping time as possible.
Specimen Required
Container/Tube:
Preferred: Yellow top (ACD solution B)
Acceptable: Yellow top (ACD solution A) or lavender top (EDTA)
Specimen Volume: 6 mL
Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.
CMH COLLECTION: 4 mL in ACD B yellow vacutainer
Specimen Minimum Volume
4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Whole Blood ACD | Refrigerated (preferred) | 6 days |
| Ambient | 6 days |
Testing Algorithm
Additional information is available:
- Lysosomal Disorders Diagnostic Algorithm, Part 1
-Newborn Screen Follow-up for Mucopolysaccharidosis Type I Decreased Alpha-L-Iduronidase Activity
Useful For
Diagnosis of mucopolysaccharidosis I, Hurler, Scheie, and Hurler-Scheie syndromes in leukocytes
This test is not useful for determining carrier status.
Reject Due To
| Gross hemolysis | Reject |
Day(s) Performed
Preanalytical processing: Monday through Saturday.
Testing performed: Monday, Thursday
Report Available
2 to 5 daysReporting Name
Alpha-L-Iduronidase, LeukocytesReference Values
≥2.06 nmol/hour/mg protein
An interpretive report will be provided.
Method Name
Flow Injection Analysis-Tandem Mass Spectrometry (FIA-MS/MS)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82657