Home
HelpTest Code IDUAW Alpha-L-Iduronidase, Leukocytes
Ordering Guidance
This test is preferred for diagnostic testing. For carrier detection, order IDUA / Mucopolysaccharidosis Type I, IDUA Gene Sequencing with Deletion/Duplication, Varies.
Shipping Instructions
For optimal isolation of leukocytes, it is recommended the specimen arrive refrigerated within 6 days of collection to be stabilized. Pre-analytical processing is performed Monday through Friday and Sunday. This test may be canceled if specimens are outside of stability when processing occurs. Collect and package specimens for arrival on days when processing is performed.
Specimen Required
Container/Tube:
Preferred: Yellow top (ACD solution B)
Acceptable: Yellow top (ACD solution A) or lavender top (EDTA)
Specimen Volume: 6 mL
Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.
CMH COLLECTION: 4 mL in ACD B yellow vacutainer
Specimen Minimum Volume
4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Whole Blood ACD | Refrigerated (preferred) | 6 days |
| Ambient | 6 days |
Testing Algorithm
Additional information is available:
- Lysosomal Disorders Diagnostic Algorithm, Part 1
-Newborn Screen Follow-up for Mucopolysaccharidosis Type I Decreased Alpha-L-Iduronidase Activity
Useful For
Diagnosis of mucopolysaccharidosis I, Hurler, Scheie, and Hurler-Scheie syndromes in leukocytes
This test is not useful for determining carrier status.
Reject Due To
| Gross hemolysis | Reject |
Day(s) Performed
Preanalytical processing: Monday through Friday, Sunday
Testing performed: Monday, Thursday
Report Available
2 to 5 daysReporting Name
Alpha-L-Iduronidase, LeukocytesReference Values
≥2.06 nmol/hour/mg protein
An interpretive report will be provided.
Method Name
Flow Injection Analysis-Tandem Mass Spectrometry (FIA-MS/MS)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82657