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Test Code IA2 Islet Antigen 2 (IA-2) Antibody, Serum


Ordering Guidance


Islet cell antigen 2 (IA2) testing is available individually (this test) and with glutamic acid decarboxylase 65-kilodalton isoform (GAD65), insulin, and zinc transporter 8 (ZnT8) antibodies as a part of DBS1 / Diabetes Mellitus Type 1 Evaluation, Serum. The evaluation is most appropriate to order in the following clinical contexts:

-Distinguishing type 1 (autoimmune) diabetes mellitus from type 2 diabetes mellitus

-Identifying individuals at risk of type 1 diabetes (including high-risk relatives of patients with diabetes) 

-Predicting future insulin requirement treatment in patients with adult-onset diabetes

 

Individual antibody testing would be more appropriate if 1, 2, or 3 of the analytes (GAD65, IA-2, insulin, ZnT8 antibodies) have already been tested and reported negative, and the provider wishes to test for the balance of remaining untested analytes only.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Children's Mercy Hospital Note:

CMH COLLECTION: 3 mL in red gel vacutainer

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Useful For

Clinical distinction of type 1 from type 2 diabetes mellitus

 

Identification of individuals at risk of type 1 diabetes (including high-risk relatives of patients with diabetes)

 

Prediction of future need for insulin treatment in adult-onset diabetic patients

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Day(s) Performed

Monday through Friday

Report Available

3 to 9 days

Reporting Name

IA-2 Ab, S

Reference Values

≤0.02 nmol/L

Reference values apply to all ages.

Method Name

Radioimmunoassay (RIA)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86341