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Test Code HIAA 5-Hydroxyindoleacetic Acid, 24 Hour, Urine


Ordering Guidance


This test is the preferred test for measurement of 5-hydroxyindoleacetic acid concentrations. If a random urine collection is preferred, order HIAAR / 5-Hydroxyindoleacetic Acid, Random, Urine.



Necessary Information


1. Collection duration and urine volume in milliliters are required.

2. Patient's age and sex are required.



Specimen Required


Patient Preparation:

1. Some medications could interfere with test results. If medically feasible, for 48 hours before specimen collection, patient should not take the following medications:

-Acetaminophen (Tylenol or generic versions)

-Tryptophan containing supplements

2. For 48 hours prior to, as well as during, the urine collection, the patient should limit the following to one serving per day:

-Fruits

-Vegetables

-Nuts

-Caffeinated beverages or foods

 

Supplies: Urine Tubes, 10 mL (T068)

Container/Tube: Plastic, 10-mL urine tube

Specimen Volume: 5 mL

Collection Instructions:

1. Add 25 mL of 50% acetic acid as preservative at start of collection. Use 15 mL of 50% acetic acid for children younger than 5 years.

2. Collect a 24-hour urine specimen.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.


Children's Mercy Hospital Note:

CMH COLLECTION: Collect 24 hour urine

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 56 days
  Frozen  365 days

Useful For

Biochemical diagnosis and monitoring of intestinal carcinoid syndrome using 24-hour urine specimens

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Day(s) Performed

Monday through Friday

Report Available

2 to 4 days

Reporting Name

5-Hydroxyindoleacetic Acid, U

Reference Values

 

5-HIAA, mg/24 hour

99th percentile cutoff

Age

Female

Male

≤23 months

≤2.7

≤2.3

24-35 months

≤3.0

≤2.6

3 years

≤3.2

≤2.9

4 years

≤3.4

≤3.2

5 years

≤3.6

≤3.6

6 years

≤3.8

≤3.9

7 years

≤4.0

≤4.2

8 years

≤4.2

≤4.5

9 years

≤4.5

≤4.8

10 years

≤4.7

≤5.1

11 years

≤4.9

≤5.3

12 years

≤5.2

≤5.6

13 years

≤5.4

≤5.8

14 years

≤5.6

≤6.1

15 years

≤5.7

≤6.3

16 years

≤5.9

≤6.4

17 years

≤6.0

≤6.6

18 years

≤6.0

≤6.7

19 years

≤6.1

≤6.8

20 years

≤6.1

≤6.9

21 years

≤6.2

≤6.9

22 years

≤6.2

≤7.0

23 years

≤6.2

≤7.0

24 years

≤6.3

≤7.1

25 years

≤6.3

≤7.2

26 years

≤6.3

≤7.2

27 years

≤6.4

≤7.3

28 years

≤6.4

≤7.4

29 years

≤6.5

≤7.5

30 years

≤6.6

≤7.5

31 years

≤6.6

≤7.6

32 years

≤6.7

≤7.7

33 years

≤6.8

≤7.7

34 years

≤6.8

≤7.8

35 years

≤6.9

≤7.9

36 years

≤6.9

≤7.9

37 years

≤7.0

≤8.0

38 years

≤7.0

≤8.1

39 years

≤7.0

≤8.2

40 years

≤7.1

≤8.2

41 years

≤7.1

≤8.3

42 years

≤7.2

≤8.4

43 years

≤7.3

≤8.5

44 years

≤7.4

≤8.6

45 years

≤7.4

≤8.7

46 years

≤7.5

≤8.8

47 years

≤7.6

≤8.9

48 years

≤7.6

≤9.0

49 years

≤7.7

≤9.1

50 years

≤7.7

≤9.2

51 years

≤7.8

≤9.3

52 years

≤7.8

≤9.4

53 years

≤7.9

≤9.5

54 years

≤8.0

≤9.6

55 years

≤8.1

≤9.7

56 years

≤8.1

≤9.7

57 years

≤8.2

≤9.8

58 years

≤8.3

≤9.8

59 years

≤8.3

≤9.8

60 years

≤8.3

≤9.9

61 years

≤8.3

≤9.9

62 years

≤8.4

≤9.9

63 years

≤8.4

≤10.0

64 years

≤8.4

≤10.0

65 years

≤8.4

≤10.0

66 years

≤8.5

≤10.1

67 years

≤8.5

≤10.1

68 years

≤8.5

≤10.1

69 years

≤8.5

≤10.2

70 years

≤8.5

≤10.2

71 years

≤8.6

≤10.2

72 years

≤8.6

≤10.2

73 years

≤8.5

≤10.1

74 years

≤8.5

≤10.1

75 years

≤8.6

≤10.1

76 years

≤8.6

≤10.0

77 years

≤8.6

≤10.0

78 years

≤8.6

≤10.0

79 years

≤8.6

≤10.0

80 years

≤8.7

≤9.9

81 years

≤8.7

≤9.9

82 years

≤8.7

≤9.9

83 years

≤8.7

≤9.9

84 years

≤8.7

≤9.9

85 years

≤8.6

≤9.8

86 years

≤8.5

≤9.8

87 years

≤8.4

≤9.7

88 years

≤8.3

≤9.7

89 years

≤8.1

≤9.5

90 years

≤7.9

≤9.4

91 years

≤7.6

≤9.2

92 years

≤7.4

≤9.0

93 years

≤7.1

≤8.8

94 years

≤7.0

≤8.7

= 95 years

≤6.9

≤8.6

 

For SI unit Reference Values, see www.mayocliniclabs.com/order-tests/si-unit-conversion.html

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

83497

Urine Preservative Collection Options

Note: The addition of preservative must occur prior to beginning the collection.

Ambient (no additive)

No

Refrigerate (no additive)

OK

Frozen (no additive)

OK

50% Acetic Acid

Preferred

Boric Acid

OK

Diazolidinyl Urea

No

6M Hydrochloric Acid

OK

6M Nitric Acid

OK

Sodium Carbonate

OK

Toluene

OK