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HelpTest Code EPO Erythropoietin, Serum
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.6 mL
Collection Instructions:
1. Morning collection, 7:30 a.m.-12 p.m. is preferred due to diurnal variation. For more information see Cautions.
2. Centrifuge and aliquot serum into a plastic vial.
CMH COLLECTION: 2 mL in red gel vacutainer
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days | ||
| Ambient | 7 days |
Testing Algorithm
The following algorithms are available in Special Instructions:
-Erythrocytosis Evaluation Testing Algorithm
-Myeloproliferative Neoplasm: A Diagnostic Approach to Bone Marrow Evaluation
-Myeloproliferative Neoplasm: A Diagnostic Approach to Peripheral Blood Evaluation
Useful For
An aid in distinguishing between primary and secondary polycythemia
Differentiating between appropriate secondary polycythemia (eg, high-altitude living, pulmonary disease, tobacco use) and inappropriate secondary polycythemia (eg, tumors)
Identifying candidates for erythropoietin (EPO) replacement therapy (eg, those with chronic renal failure)
Evaluating patients undergoing EPO replacement therapy who demonstrate an inadequate hematopoietic response
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross Icterus | OK |
Day(s) Performed
Monday through Friday
Report Available
1 to 3 daysReporting Name
Erythropoietin (EPO), SReference Values
2.6-18.5 mIU/mL
Method Name
Immunoenzymatic Assay
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82668