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HelpTest Code CLZ Clozapine, Serum
Ordering Guidance
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Â
1. Collect specimen immediately before next scheduled dose.
2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Additional Information: Therapeutic range (trough level) applies to specimens collected immediately prior to next dose.
CMH COLLECTION: 1.5 mL blood in Red vacutainer
Specimen Minimum Volume
0.6 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 7 days |
Useful For
Monitoring patient compliance of clozapine treatment
An aid to achieving desired serum levels
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Day(s) Performed
Monday through Friday
Report Available
3 to 5 daysReporting Name
Clozapine, SReference Values
Clozapine
Therapeutic range: 350-600 ng/mL
Norclozapine
Therapeutic range: Not well established
Clozapine + Norclozapine
Therapeutic range: Not well established
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
80159